Modelling MOG antibody-associated disorder and neuromyelitis optica spectrum disorder in animal models: spinal cord manifestations

Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) or aquaporin 4 (AQP4-IgG) are associated with CNS inflammatory disorders. We directly compared MOG35-55-induced experimental autoimmune encephalomyelitis exacerbated by MOG- and AQP4-IgG (versus isotype IgG, Iso-IgG). Disease severity was highest after MOG-IgG application. administration increased disease incidence Iso-IgG. Inflammatory lesions appeared earlier distinct localizations administration. AQP4 intensity more reduced AQP4- than at acute phase. The described models suitable for comparative analyses of pathological features the investigation therapeutic interventions.